Neurexpert was founded in 2011 to provide assays delivering data on compound potency and efficacy at the native target. These assays bridge a gap between in vitro and in vivo screens, confirming mechanism of
action and provide essential functional and mechanistic data on the neural mechanisms underlying higher brain functions such as cognition and sensory processing.
Our expertise can assist project progression at all stages of the drug discovery process, from target validation and early stage screening through to functional biomarker studies to aid clinical development.
Stuart Neale, PhD, Chief Executive Officer, is an electrophysiologist and neuroscientist with over 20 years’ experience studying physiological variables in pharmaceutical, academic and clinical research environments. He has extensive expertise in developing electrophysiology assays for drug discovery in companies ranging from start-ups through to large pharma, and successfully integrating these into the output of multidisciplinary project teams engaged in drug discovery and early development activities across a range of diseases of the nervous system.
Tom Salt, PhD, Chief Scientific Officer, is a Fellow of the British Pharmacological Society, Emeritus Professor at University College London (UCL), and Honorary Professor at The Institute of Neuroscience, Newcastle University. His research encompasses neurotransmitter pharmacology in the visual and somatosensory/pain systems, and the functional consequences of retinal degenerations in eye diseases. Tom has published over 200 research and review papers including in journals such as Nature, Science, Nature Neuroscience, PNAS, and is a member of several editorial boards. He has worked in the pharmaceutical industry, and has acted as a consultant and adviser to industry.
Fiona LeBeau, PhD, Consultant in Neuronal Circuit Physiology, is Lecturer in Neural Networks, at Newcastle University. Fiona has extensive experience and expertise studying neuronal network activity using both in vitro and in vivo approaches, and has worked on several collaborative projects with industry. Her research interests are focused on the changes that occur in hippocampal and cortical network oscillations, in both neuropsychiatric disease (such as schizophrenia) and neurodegenerative diseases (such as Lewy body dementia).
Beth Dennis, MRes, Laboratory Manager has a First Class degree in Biology and a masters degree in Neuroscience. Beth joined us in 2017 and has expertise in a range of electrophysiological techniques which are being focused on expanding our assays based around network oscillations and recordings from human tissue. Beth is also currently sudying for a PhD funded by Neurexpert.